crux

n.

（问题的）中心，核心，结症；坩埚；关键；症结

crux of the matter问题的关键

1. Therein lies the crux of the matter.
   问题的关键就在那里。
2. Now we come to the crux of the problem.
   现在我们来谈问题的症结所在。
3. This is the first main crux of dynamic theory.
   这是动态学说第一个主要的难题。

The capsule and colorectal-cancer screening--the crux of the matter
Laminin: The Crux of Basement Membrane Assembly
Crux medicorum ulcerated radiation-induced fibrosis - successful therapy with pentoxifylline and vitamin E
Informed and shared decision-making: the crux of patient-centered care.
The crux of the UGDP. Spurious results and biologically inappropriate data analysis.
Crux's Crux's crux
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy.
Phenotype variability in progranulin mutation carriers: a clinical, neuropsychological, imaging and genetic study.
Plasma progranulin levels predict progranulin mutation status in frontotemporal dementia patients and asymptomatic family members
A Polymorphism in CALHM1 Influences Ca2+ Homeostasis, Aβ Levels, and Alzheimer's Disease Risk